Endocrine Abstracts

Introduction: Malignant pheochromocytomas and paragangliomas (PPGLs) are rare, and knowledge of the natural history is limited. Material Methods: Data of 7 (7.6%) (out of 109) patients with malignant PPGLs referred to a Tertiary Centre of Endocrinology from Bucharest, Romania, were retrospectively collected. Follow-up ranged from 2004 to 2022. Demographic data, genetic status, site and size of primary tumor, biochemical activity, metastasis time (synchro...

At least one fifth of pituitary adenomas exhibit plurihormonality when using immunohistochemistry for anterior pituitary hormones. However, the correlation with clinical features is weak, without an agreement upon pathological predictors of tumour behaviour.The aim was to determine the immunoreactivity for anterior pituitary hormones and alpha subunit in 276 consecutive pituitary adenoma patients, aged 22–79 years (44.3±8), 154 F/ 122 M: 83 acr...

We present an experimental study on human prolactinoma in cell culture from a patient that partially responded to cabergoline treatment and had to have surgical treatment.Aim: The aim of the study was to assess the effect of cabergoline, dopamine and melatonin on prolactin secretion and cell proliferation in human prolactinoma cell culture from a patient that had transsphenoidal surgery.Material and methods: Tissue specimen derived...

It has been generally believed that clinically functioning pituitary adenomas are highly specialized neoplastic lesions, which produce a unique hormone. Increasing body of evidence argue against this concept, since about half of prolactinomas (PRM) and approximately 60% of TSH-secreting adenomas are multihormonal and 30–40% of GH-secreting adenomas co-secrete PRL. Most of classically considered null cell adenomas have been proved to be immunohistochemical positive for gon...